Several middle ear (ME) pathologies are associated with ME gas deficit. These include in particular the chronic otitis media diseases that are associated with inflammation (hence, increased ME mucosal permeability). The ME gas deficit is thought to be a result of the inflammation-induced damage to the ME mucosa. This damage leads to the loss of the ME gas, which is essential for the proper functioning of the ME. The ME gas loss is associated with various symptoms, including hearing loss, tinnitus, and vertigo. The ME gas loss is a significant problem in the treatment of ME pathologies, as it can lead to the failure of the ME to function properly. Therefore, it is essential to understand the mechanisms underlying the ME gas loss in inflammatory conditions and to develop effective treatments to prevent or reverse this condition.