The RNA exosome complex plays a crucial role in the degradation of nuclear transcripts. The adaptor protein ZFC3H1 is essential for the function of the RNA exosome, ensuring its proper targeting and activity. This complex is vital for maintaining the balance of gene expression and preventing the accumulation of aberrant transcripts. The study of ZFC3H1 and the RNA exosome complex provides valuable insights into the mechanisms of nuclear RNA degradation and its implications for cellular processes.