[Association of SPO11 and GST gene polymorphisms with idiopathic male infertility in ethnic Han Chinese].
Copyright policy )[Association of SPO11 and GST gene polymorphisms with idiopathic male infertility in ethnic Han Chinese].
To explore the possible roles of polymorphisms of SPO11 and glutathionine S-transferase (GST) genes in idiopathic male infertility in a ethnic Han Chinese population from Henan.Multiplex PCR and DNA sequencing were performed to determine the SPO11 c.517C>T(rs28368082) and GST genes (GSTM1, GSTT1, GSTP1) polymorphisms in 216 idiopathic male infertility cases and 198 normal samples.The frequencies of the SPO11 CC and CT genotypes were 87.5% (189/216) and 12.5% (27/216) in the patients, and 97.5% (193/198) and 2.5% (5/198) in the controls, respectively. The frequencies of SPO11 CC and CT genotypes, the A>G transition at nucleotide 313 in the exon 5 of the GSTP1 gene, and the frequencies of combined genotypes GSTM1 (-/-), GSTT1 (+/+), GSTP1 (AA) and SPO11 (CT) were significantly different between the two groups (PG transition at nucleotide 313 in the exon 5 of the GSTP1 gene, and the combined genotypes of GSTM1 (-/-), GSTT1 (+/+), GSTP1 (AA) and SPO11 (CT) may be associated with idiopathic male infertility in ethnic Han Chinese.
- Zhengzhou People's Hospital China (People's Republic of)
Adult, Male, China, Endodeoxyribonucleases, Polymorphism, Genetic, Base Sequence, Genotype, Sequence Analysis, DNA, Linkage Disequilibrium, Asian People, Gene Frequency, Glutathione S-Transferase pi, Mutation, Odds Ratio, Humans, Genetic Predisposition to Disease, Alleles, Infertility, Male, Glutathione Transferase
Adult, Male, China, Endodeoxyribonucleases, Polymorphism, Genetic, Base Sequence, Genotype, Sequence Analysis, DNA, Linkage Disequilibrium, Asian People, Gene Frequency, Glutathione S-Transferase pi, Mutation, Odds Ratio, Humans, Genetic Predisposition to Disease, Alleles, Infertility, Male, Glutathione Transferase
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