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Association between HLA-DRB1*01 and HLA-Cw*08 and outcome following HTLV-I infection.

Association between HLA-DRB1*01 and HLA-Cw*08 and outcome following HTLV-I infection.
Human T cell lymphotropic virus type I (HTLV-I)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is an inflammatory disease which occurs in less than 2% of HTLV-I -infected individuals. High proviral load, high HTLV-I-specific CD8+ cytotoxic T lymphocyte frequency (CTL) and host genetic factors such as HLA all appear to be associated with HTLV-I infection. Previous studies have shown that HLA-DRB1*01 increases the risk of HAM/TSP in Japanese HTLV-I infected individuals.To investigate the association between HLA class II DRB1 alleles and HLA class I alleles (HLA-Cw*08, B54, A*02 and A-30) in HTLV-I infected individuals in Mashhad.Here we determined the frequency of HLA class II DRB1, using INNO-LIPA reverse hybridization line probe assay, and HLA class I alleles (HLA-Cw*08,B54, A*02 and A-30) by PCR-SSCP method in healthy controls, HAM/TSP patients and HTLV-I infected individuals born and resident in Mashhad.The frequency of HLA-DRB1*01 alleles in this population was different from other areas of Iran. The frequency of HLA-DRB1*01 was significantly increased in HAM/TSP patients compared with carriers (p 0.028; OR=9.4). The frequency of HLA-Cw*08 was also significantly increased in HAM/TSP patients compared with controls (p=0.03; OR=13.5).Our results may suggest that possession of HLA-DRB1*01 increases the risk of HAM/TSP in HTLV-I-infected individuals and HLA-Cw*08 correlates with low CTL immune response in HAM/TSP patients.
- University of Salford United Kingdom
- Mashhad University of Medical Sciences Iran (Islamic Republic of)
Cytotoxicity, Immunologic, Male, Risk, Human T-lymphotropic virus 1, Research Support, Non-U.S. Gov't, HLA-C Antigens, HLA-DR Antigens, HTLV-I Infections, Paraparesis, Tropical Spastic, Gene Frequency, Journal Article, Humans, Female, HLA-DRB1 Chains
Cytotoxicity, Immunologic, Male, Risk, Human T-lymphotropic virus 1, Research Support, Non-U.S. Gov't, HLA-C Antigens, HLA-DR Antigens, HTLV-I Infections, Paraparesis, Tropical Spastic, Gene Frequency, Journal Article, Humans, Female, HLA-DRB1 Chains
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