Kardiologiia

Article . 2016

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[Genetic Predictors of Unfavorable Course in High Risk Patients With Ischemic Heart Disease. Data of Follow-up for Two Years.].

descriptionPublicationkeyboard_double_arrow_right Article 23 Apr 2016 Russian Journal:Kardiologiia, volume 44 (issn: 0022-9040,

Authors: D A, Zateĭshchikov; O S, Chumakova; A A, Zateĭshchikova; I V, Zotova; L O, Minushkina; D A, Chudakova; V V, Nosikov; +1 Authors

pmid: 15699916

[Genetic Predictors of Unfavorable Course in High Risk Patients With Ischemic Heart Disease. Data of Follow-up for Two Years.].

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Abstract

Prognostic value of clinical parameters and polymorphisms of apo-B, apo-E, LPL, , PPARA, PPARG2 genes was studied in 154 patients with acute unstable angina. Duration of follow-up was 2 years. Diabetes (OR 3.29, 1.28-8.50, p=0.014), history of stroke (OR 6.11, 1.21-31.00, p=0.029), changes of terminal part of ventricular complex on ECG, recorded during acute phase of ischemic heart disease (OR 2.19, 1.01-4.57, p=0.046), and genotype II of polymorphic marker ID of apoB gene (OR 2.20, 1.06-4.57, p=0.027) were independent predictors of unfavorable course of ischemic heart disease. Thus genetic factors play a role not only in formation of coronary atherosclerosis but determine the course of ischemic heart disease.

Keywords

Risk Factors, Myocardial Ischemia, Humans, Angina, Unstable, Coronary Artery Disease, Apolipoproteins B, Follow-Up Studies

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