Psychological response to cancer: role of 5-HTTLPR genetic polymorphism of serotonin transporter.
Copyright policy )Psychological response to cancer: role of 5-HTTLPR genetic polymorphism of serotonin transporter.
5-HTTLPR genetic polymorphism of serotonin transporter (SERT) and stressful life events facilitate depression. The aim of this investigation was therefore to determine the correlations between SERT polymorphism and mental adjustment to cancer.Breast cancer patients early after surgery, and subjects with various advanced tumours were recruited, evaluated using the Mini Mental Adjustment to Cancer Scale and Hospital Anxiety and Depression Scale (HADS), and genotyped.In early breast cancer patients (n=53), hopelessness-helplessness (HH) and anxious preoccupation (AP) significantly correlated with depression and anxiety; avoidance (AV) correlated with anxiety. Advanced cancer patients (n=73) displayed similar correlations, and a negative correlation of HADS depression with fighting spirit (FS) and AV. The stratification for 5-HTTLPR showed that early breast cancer carriers of the L/L variant displayed a significant correlation between HH and depression.Among early breast cancer patients, a specific set, characterized by their 5-HTTLPR variant, display differential correlations between HH and depression, with possible implications for treatment options.
- University of Trieste Italy
- University of Ferrara Italy
Serotonin Plasma Membrane Transport Proteins, Depression, cancer; psychopathology.serotonin transport, Breast Neoplasms, Anxiety, psychopathology.serotonin transport, Polymorphism, Single Nucleotide, Psychological Response to Cancer, Adaptation, Psychological, 5-httlpr; Psychological Response to Cancer, cancer, Humans, Female, Genetic Predisposition to Disease, 5-httlpr
Serotonin Plasma Membrane Transport Proteins, Depression, cancer; psychopathology.serotonin transport, Breast Neoplasms, Anxiety, psychopathology.serotonin transport, Polymorphism, Single Nucleotide, Psychological Response to Cancer, Adaptation, Psychological, 5-httlpr; Psychological Response to Cancer, cancer, Humans, Female, Genetic Predisposition to Disease, 5-httlpr
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