Role of polymorphisms of the inflammatory response genes and DC-SIGNR in genetic susceptibility to SARS and other infections.
Copyright policy )Role of polymorphisms of the inflammatory response genes and DC-SIGNR in genetic susceptibility to SARS and other infections.
1. A genetic risk-association study involving more than 1200 subjects showed individuals homozygous for L-SIGN tandem repeats are less susceptible to SARS infection. 2. This was supported by in vitro binding studies that demonstrated homozygous L-SIGN, compared to heterozygous, had higher binding capacity for SARS coronavirus (SARS-CoV), with higher proteasome-dependent viral degradation. In contrast, homozygous L-SIGN demonstrated lower binding capacity for HIV1-gp120.3. Genetic-association studies for single nucleotide polymorphisms of the inflammatory response genes, namely TNF-alpha, INF-alpha, INF-beta, INF-gamma, IL1-alpha, IL1-beta, IL-4, IL-6 and iNOS, failed to show a significant association with SARS clinical outcomes or susceptibility.
Research Fund for the Control of Infectious Diseases: Research Dissemination Reports (Series 2)
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- University of Hong Kong China (People's Republic of)
- University of Hong Kong (香港大學) China (People's Republic of)
Adult, Male, Severe Acute Respiratory Syndrome - genetics - physiopathology, Tumor Necrosis Factor-alpha - genetics - metabolism, Receptors, Cell Surface, Communicable Diseases, Genetic, Gene Frequency, Lectins, Receptors, SARS Virus - genetics - metabolism, Confidence Intervals, Odds Ratio, Humans, Genetic Predisposition to Disease, Lectins, C-Type, C-Type - genetics, Polymorphism, Receptors, Cell Surface - genetics, Alleles, Probability, Analysis of Variance, Polymorphism, Genetic, Middle Aged, Cell Adhesion Molecules - genetics, Severe acute respiratory syndrome-related coronavirus, Tandem Repeat Sequences, Cytokines - genetics - metabolism, Case-Control Studies, Communicable Diseases - genetics - physiopathology, Cytokines, Female, Lectins, C-Type - genetics, Cell Surface - genetics, Cell Adhesion Molecules
Adult, Male, Severe Acute Respiratory Syndrome - genetics - physiopathology, Tumor Necrosis Factor-alpha - genetics - metabolism, Receptors, Cell Surface, Communicable Diseases, Genetic, Gene Frequency, Lectins, Receptors, SARS Virus - genetics - metabolism, Confidence Intervals, Odds Ratio, Humans, Genetic Predisposition to Disease, Lectins, C-Type, C-Type - genetics, Polymorphism, Receptors, Cell Surface - genetics, Alleles, Probability, Analysis of Variance, Polymorphism, Genetic, Middle Aged, Cell Adhesion Molecules - genetics, Severe acute respiratory syndrome-related coronavirus, Tandem Repeat Sequences, Cytokines - genetics - metabolism, Case-Control Studies, Communicable Diseases - genetics - physiopathology, Cytokines, Female, Lectins, C-Type - genetics, Cell Surface - genetics, Cell Adhesion Molecules
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