[Analysis on haplotypes of five HLA loci in southern Chinese Han population by sequence-based typing].
Copyright policy )[Analysis on haplotypes of five HLA loci in southern Chinese Han population by sequence-based typing].
To analyze the polymorphism and haplotypes of HLA-A, B, Cw, DRB1 and DQB1 loci in Chinese Han population.A total of 186 unrelated healthy individuals from southern China were analyzed by sequence-based typing. Two-, three-, and five-locus haplotypes were estimated using the Expectation Maximization Algorithm. RESULTST: Twenty-eight alleles for the HLA-A locus, 49 HLA-B alleles, 24 HLA-C alleles, 29 HLA-DRB1 alleles and 20 HLA-DQB1 alleles were detected. The A*0207-B*4601(10.81%), A*3303-B*5801(6.14%), B*4601-DRB1*0901(6.22%), B*4001*-DRB1*0901(3.78%), DRB1*090-DQB1*0303 (12.16%) and DRB1*1202-DQB1*0301(8.38%), A*0207-B*4601-Cw*0102 (10.75%), A*3303-B*5801-Cw*0302 (5.14%), A*0207-B*4601-DR*0901(5.07%), A*3303-B*5801-DRB1*0301(2.96%), A*0207-B*4601-Cw*0102-DRB1*0901-DQB1*0303(4.87%) and A*1101-B*1301-Cw*0304-DRB1*1501-DQB1*0601(2.43%) were the most common haplotypes in the southern Chinese Han population.The results have shown the characteristics of the five HLA loci haplotype distribution and provided more information in anthropology, disease association studies and transplantation.
- Shenzhen Blood Center China (People's Republic of)
- Gulf Coast Regional Blood Center United States
Adult, Male, China, Base Sequence, HLA-DR Antigens, Genetics, Population, Haplotypes, Population Groups, HLA Antigens, HLA-B Antigens, HLA-DQ Antigens, HLA-DQ beta-Chains, Humans, Female, Alleles, HLA-DRB1 Chains
Adult, Male, China, Base Sequence, HLA-DR Antigens, Genetics, Population, Haplotypes, Population Groups, HLA Antigens, HLA-B Antigens, HLA-DQ Antigens, HLA-DQ beta-Chains, Humans, Female, Alleles, HLA-DRB1 Chains
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