Contribution of low density lipoprotein receptor-related protein genotypes to coagulation factor VIII levels in thrombotic women.
Copyright policy )Contribution of low density lipoprotein receptor-related protein genotypes to coagulation factor VIII levels in thrombotic women.
The contribution of low density lipoprotein (LDL) receptor-related protein (LRP) to variance of factor VIII (FVIII) levels in plasma was investigated in thrombotic women through analysis of frequent LRP genotypes. The G allele of the LRP -25C/G polymorphism, predicting increased LRP expression, was associated with 15% and 18% mean reductions of FVIII activity and protein levels, respectively. The combination of -25C/G LRP polymorphism with FVIII D1241E and ABO polymorphisms produced a gradient of FVIII levels, thus supporting the notion that several factors, acting in FVIII biosynthesis, post-translational modification and removal from circulation, have additive effects on the variance of FVIII levels in plasma.
Adult, VENOUS THROMBOSIS; LRP genotypes; FVIII levels, Factor VIII, Polymorphism, Genetic, Genotype, LRP genotypes; FVIII levels; venous thrombosis, Humans, Female, Thrombosis, Protein Processing, Post-Translational, Low Density Lipoprotein Receptor-Related Protein-1
Adult, VENOUS THROMBOSIS; LRP genotypes; FVIII levels, Factor VIII, Polymorphism, Genetic, Genotype, LRP genotypes; FVIII levels; venous thrombosis, Humans, Female, Thrombosis, Protein Processing, Post-Translational, Low Density Lipoprotein Receptor-Related Protein-1
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