Effects of tumor necrosis factor-α inhibitors in mothers and daughters concordant for HLA-B27-positive ankylosing spondylitis.
Copyright policy )Effects of tumor necrosis factor-α inhibitors in mothers and daughters concordant for HLA-B27-positive ankylosing spondylitis.
Pharmacogenomics is considered as the new frontier to predict the response to treatments and it can also be based on the comparison of family members being treated for the same condition. No data are available on the impact of anti-tumour necrosis factor (TNF)-α therapies in members of the same family with ankylosing spondylitis (AS).We describe three mother-daughter couples concordant for AS and HLA-B27, both treated with TNF-α inhibitors, for whom the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), Bath Ankylosing Spondylitis Functional Index (BASFI), and Ankylosing Spondylitis Disease Activity Score (ASDAS)-CRP were evaluated during a follow-up of 24 months.All patients manifested improvements of all scores, but the daughters had a more prominent effect achieving faster complete disease remission.We hypothesise that longer standing chronic inflammation and older age may cause a less prompt and effective response to treatment in SA when compared with their genetically related controls.
- University of Milan Italy
- University of Padua Italy
- Humanitas Research Hospital Italy
- Catholic University of the Sacred Heart Italy
- University of Siena Italy
Ankylosing, Adult, Time Factors, Time Factor, Adolescent, Genotype, Immunology, Mothers, Severity of Illness Index, Etanercept, Immunosuppressive Agent, Young Adult, Rheumatology, adalimumab, Spondyloarthritis, Immunology and Allergy, Humans, Age Factor, Spondylitis, Ankylosing, HLA-B27 Antigen, Aged, pharmacogenomics, Familial spondyloarthritis, Tumor Necrosis Factor-alpha, Pharmacogenetic, Remission Induction, Adolescent; Adult; Age Factors; Aged; Female; Genotype; HLA-B27 Antigen; Humans; Immunosuppressive Agents; Middle Aged; Pedigree; Pharmacogenetics; Phenotype; Remission Induction; Severity of Illness Index; Spondylitis, Ankylosing; Time Factors; Treatment Outcome; Tumor Necrosis Factor-alpha; Young Adult; Mothers, Adalimumab, Age Factors, familial spondyloarthritis, Middle Aged, Pedigree, Phenotype, Treatment Outcome, Pharmacogenetics, Adalimumab; Etanercept; Familial spondyloarthritis; Pharmacogenomics; Immunology and Allergy; Rheumatology; Immunology, Female, Pharmacogenomics, etanercept, Immunosuppressive Agents, Human, Spondylitis
Ankylosing, Adult, Time Factors, Time Factor, Adolescent, Genotype, Immunology, Mothers, Severity of Illness Index, Etanercept, Immunosuppressive Agent, Young Adult, Rheumatology, adalimumab, Spondyloarthritis, Immunology and Allergy, Humans, Age Factor, Spondylitis, Ankylosing, HLA-B27 Antigen, Aged, pharmacogenomics, Familial spondyloarthritis, Tumor Necrosis Factor-alpha, Pharmacogenetic, Remission Induction, Adolescent; Adult; Age Factors; Aged; Female; Genotype; HLA-B27 Antigen; Humans; Immunosuppressive Agents; Middle Aged; Pedigree; Pharmacogenetics; Phenotype; Remission Induction; Severity of Illness Index; Spondylitis, Ankylosing; Time Factors; Treatment Outcome; Tumor Necrosis Factor-alpha; Young Adult; Mothers, Adalimumab, Age Factors, familial spondyloarthritis, Middle Aged, Pedigree, Phenotype, Treatment Outcome, Pharmacogenetics, Adalimumab; Etanercept; Familial spondyloarthritis; Pharmacogenomics; Immunology and Allergy; Rheumatology; Immunology, Female, Pharmacogenomics, etanercept, Immunosuppressive Agents, Human, Spondylitis
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