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Mechanism governing reversal of multidrug resistance in human breast carcinoma cells by chelerythrine.

descriptionPublicationkeyboard_double_arrow_right Article 01 Feb 2011 English Publisher:Zhongguo Yi Xue Ke Xue Yuan Xue BaoJournal:Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae, volume 33 (issn: 1000-503X,

Authors: Ming Hui W; Yu Jie S; Jun G; Yu J; Li-Juan W; Zhe C;

doi: 10.3881/j.issn.1000-503x.2011.01.010

pmid: 21375937

Mechanism governing reversal of multidrug resistance in human breast carcinoma cells by chelerythrine.

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Abstract

To explore the mechanism governing the reversal of multidrug resistance in human breast carcinoma cells by chelerythrine.Reverse transcription-polymerase chain reaction (RT-PCR) and Western blot were used to determine the expressions of protein kinase Cα (PKCα) and multidrug resistance-related genes ABCG2, ABCC1, MDR1, and P-glycoprotein (P-gp) in MCF-7Taxol cells after treatment with chelerythrine and phorbol-12-myristate-13-acetate (PMA). Also, the antitumor effect of PMA or chelerythrine and effects of PKCα activator or inhibitor in combination with paclitaxel or adriamycin on multidrug resistance in MCF-7Taxol cells were evaluated by MTT.RT-PCR or Western blot showed that the expressions of MDR1 and P-gp were significantly higher in MCF-7Taxol cells exposed to PMA stimuli (both P0.05).PKCα inhibitor chelerythrine can reverse multidrug resistance in breast carcinoma cells by inhibiting the expressions of MDR1 and P-gp expression in vitro.

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Nanjing Medical University
China (People's Republic of)

Keywords

Benzophenanthridines, ATP Binding Cassette Transporter, Subfamily B, Drug Resistance, Neoplasm, Cell Line, Tumor, Humans, Breast Neoplasms, Female, ATP Binding Cassette Transporter, Subfamily B, Member 1, Drug Resistance, Multiple

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