Bdp, a new member of a family of DNA-binding proteins, associates with the retinoblastoma gene product.
Copyright policy )Bdp, a new member of a family of DNA-binding proteins, associates with the retinoblastoma gene product.
We have cloned a gene, BDP, encoding a protein with homology to the retinoblastoma-binding proteins Rbp1 and Rbp2. It also has homology to DNA-binding proteins such as Bright, a B-cell-specific trans-activator, and the Drosophila melanogaster dead ringer gene product. Like MyoD, Bdp binds to the COOH-terminal region of pRb through its conserved region and to hypophosphorylated pRb. It also binds to the MAR of the immunoglobulin heavy-chain locus. Thus Bdp may contribute to the transcriptional regulation of genes involved in differentiation and tissue-specific expression.
- University of Ferrara Italy
- University of Siena Italy
- Thomas Jefferson University United States
Expressed Sequence Tags, Homeodomain Proteins, Chromosomes, Human, Pair 15, Binding Sites, DNA, Complementary, Base Sequence, Brain Neoplasms, Molecular Sequence Data, Chromosome Mapping, DNA-Binding Proteins, Molecular Weight, Drosophila melanogaster, Animals, Drosophila Proteins, Humans, Insect Proteins, Amino Acid Sequence, Glioblastoma, Gene Library, HeLa Cells
Expressed Sequence Tags, Homeodomain Proteins, Chromosomes, Human, Pair 15, Binding Sites, DNA, Complementary, Base Sequence, Brain Neoplasms, Molecular Sequence Data, Chromosome Mapping, DNA-Binding Proteins, Molecular Weight, Drosophila melanogaster, Animals, Drosophila Proteins, Humans, Insect Proteins, Amino Acid Sequence, Glioblastoma, Gene Library, HeLa Cells
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).34 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!