Journal of microbiology epidemiology immunobiology

Article . 2016

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Journal of microbiology epidemiology immunobiology

Article . 2015

Data sources: DOAJ

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[STUDY OF THE ROLE OF INNATE IMMUNITY FACTORS (TLR2, HBD-2, TNF-α, TGF-β) IN PERIODONTITIS PATHOGENESIS].

descriptionPublicationkeyboard_double_arrow_right Article 01 Dec 2015 Russian Publisher:Central Research Institute for EpidemiologyJournal:Zhurnal mikrobiologii, epidemiologii i immunobiologii (issn: 0372-9311,

Authors: L. V Gankovskaya; N. M Helminskaya; O. A Svitich; E. A Molchanova; V. V Grechenko; E. V Sokolova; K. V Rusanova;

pmid: 26950997

[STUDY OF THE ROLE OF INNATE IMMUNITY FACTORS (TLR2, HBD-2, TNF-α, TGF-β) IN PERIODONTITIS PATHOGENESIS].

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Abstract

Study of the role of innate immunity factors, namely, expression of TLR2 and HBD-2 genes, as well as TNF-α arid TGF-β in pathogenesis of periodontium tissue inflammation.59 individuals with periodontitis illnesses were included into the study; 15 healthy donors represented the comparison group. Study of the TLR2 and HBD-2 gene expression levels was carried out by rRT-PCR, cytokine production evaluation--by EIA.The results of the study have shown the presence of TLR-mediated disbalance in the innate immunity system in the periodontium tissue during chronic generalized periodontitis. TLR2 gene hyperexpression was accompanied by the reduction of expression of anti-microbial peptide HBD-2, as well as an increase of production of TNF-αand TGF-P by epithelial cells of periodontium mucosa. Conclusion.-The study carried out has shown that disturbance of molecular mechanisms of innate immunity system has an important place in pathogenesis of periodontitis. -

Keywords

Adult, Male, Periodontium, beta-Defensins, Microbiology, Transforming Growth Factor beta, Humans, Periodontitis, periodontitis, innate immunity, Tumor Necrosis Factor-alpha, Mouth Mucosa, Epithelial Cells, Middle Aged, cytokines, QR1-502, Immunity, Innate, Toll-Like Receptor 2, toll-like receptors, Gene Expression Regulation, Case-Control Studies, Female, defensins, Signal Transduction

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