[Clinicopathologic study and immunohistochemistry comparison of Pax2, p53 and Ki-67 in low- and high-grade ovarian serous carcinomas].
Copyright policy )[Clinicopathologic study and immunohistochemistry comparison of Pax2, p53 and Ki-67 in low- and high-grade ovarian serous carcinomas].
To evaluate the two-tier system for the grading of ovarian serous carcinomas, and to analyze Pax2, p53, Ki-67 protein expression and their prognostic values for low- and high-grade ovarian serous carcinomas.A total of 38 cases of low-grade and 100 cases of high-grade ovarian serous carcinomas were selected based on the two-tier grading system. Immunohistochemistry was used to detect Pax2, p53 and Ki-67 protein expression in all cases. Correlation of the two-tier system with immunohistochemical results and prognostic parameters were performed.(1) The overall survival, disease-free survival and 5-year survival rates were significantly higher in the low-grade serous carcinoma cases than in the high-grade cases (P 0.05).The two-tier system for the grading of ovarian serous carcinomas has a good prognostic value. There are significantly differences in expressions of Pax2, p53 and Ki-67 between low- and high-grade ovarian serous carcinomas. Compared with p53 and Ki-67, Pax2 is likely a better prognostic indicator for ovarian serous carcinoma.
- Fudan University China (People's Republic of)
Ovarian Neoplasms, Ovary, PAX2 Transcription Factor, Membrane Proteins, Middle Aged, Immunohistochemistry, Disease-Free Survival, Cystadenocarcinoma, Serous, Survival Rate, Ki-67 Antigen, CA-125 Antigen, Humans, Female, Neoplasm Grading, Tumor Suppressor Protein p53, Follow-Up Studies, Neoplasm Staging
Ovarian Neoplasms, Ovary, PAX2 Transcription Factor, Membrane Proteins, Middle Aged, Immunohistochemistry, Disease-Free Survival, Cystadenocarcinoma, Serous, Survival Rate, Ki-67 Antigen, CA-125 Antigen, Humans, Female, Neoplasm Grading, Tumor Suppressor Protein p53, Follow-Up Studies, Neoplasm Staging
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