Journal of Pediatric Endocrinology and Metabolism

Article . 2005

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Study of genetic expression of intrauterine growth factors IGF-I and EGFR in placental tissue from pregnancies with intrauterine growth retardation.

descriptionPublicationkeyboard_double_arrow_right Article 03 May 2005 English Journal:Journal of pediatric endocrinology & metabolism : JPEM, volume 17 Suppl 3 (issn: 0334-018X,

Authors: M T, Calvo; A, Romo; J J, Gutiérrez; E, Relaño; E, Barrio; A, Ferrández Longás;

pmid: 15134305

Study of genetic expression of intrauterine growth factors IGF-I and EGFR in placental tissue from pregnancies with intrauterine growth retardation.

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Abstract

To investigate the possibility of altered gene expression of growth factors in prenatal growth retardation, we assessed expression of the genes for insulin-like growth factor-I (IGF-I) and epidermal growth factor receptor (EGFR) by RT-PCR from human placentas at term delivery in two groups: appropriate for gestational age (AGA) and pregnancies complicated with IUGR. The placentas from IUGR gestations showed reduced IGF-I expression with a significance of p = 0.008, whereas we did not find any significant differences in EGFR gene expression.

Related Organizations

University of Zaragoza
Spain

Keywords

ErbB Receptors, Fetal Growth Retardation, Pregnancy, Reverse Transcriptase Polymerase Chain Reaction, Placenta, RNA, Ribosomal, 18S, Gene Expression, Humans, Female, Insulin-Like Growth Factor I

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