[Expression and its significance of STAT3, STAT5, Survivin and Ki67 in nasal NK/T cell lymphoma].
[Expression and its significance of STAT3, STAT5, Survivin and Ki67 in nasal NK/T cell lymphoma].
To study the expression and its significance of STAT3, STAT5, Survivin and Ki67 in the Epstein-Barr virus associated nasal NK/T cell lymphoma.The expression of STAT3, STAT5, Survivin and Ki67 were detected with immunohistochemistry in 25 cases of nasal NK/T cell lymphoma, and their relationship was analyzed. Nasal cavity tissues from 20 cases of chronic sinusitis were as the control group.The positive rates of STAT3 in the lymphoma and in control group were 56% and 10%, respectively (P <0.01). The positive rates of STAT5 in the lymphoma and in control group were 68% and 15%, respectively (P <0.01). The positive rates of Survivin and Ki67 of nasal NK/T cell-lymphoma were 68% and 72%, respectively; but it in the control group was 0% and 20%, respectively, P <0.01. The expression of STAT3 was positively related to that of Survivin and Ki67(r =0. 428, P <0. 05 and r =0. 704, P <0. 01); The expression of STAT5 was not related to that of Survivin and Ki67.The pathway of STAT may play a role in the development of nasal NK/T cell lymphoma. STAT maybe take part in the formation of nasal NK/T cell lymphoma through induction of Survivin and Ki67.
- First Affiliated Hospital of Fujian Medical University China (People's Republic of)
Adult, Male, STAT3 Transcription Factor, Herpesvirus 4, Human, Adolescent, Survivin, Nose Neoplasms, Middle Aged, Inhibitor of Apoptosis Proteins, Lymphoma, Extranodal NK-T-Cell, Young Adult, Ki-67 Antigen, STAT5 Transcription Factor, Humans, Female, Microtubule-Associated Proteins, Aged
Adult, Male, STAT3 Transcription Factor, Herpesvirus 4, Human, Adolescent, Survivin, Nose Neoplasms, Middle Aged, Inhibitor of Apoptosis Proteins, Lymphoma, Extranodal NK-T-Cell, Young Adult, Ki-67 Antigen, STAT5 Transcription Factor, Humans, Female, Microtubule-Associated Proteins, Aged
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