Prognostic significance of mutant p53 protein, P-glycoprotein and glutathione S-transferase-pi in patients with unresectable non-small cell lung cancer.
Copyright policy )Prognostic significance of mutant p53 protein, P-glycoprotein and glutathione S-transferase-pi in patients with unresectable non-small cell lung cancer.
The prognostic significance of mutant p53 protein, p-glycoprotein (P-gp) and glutathione S-transferase-pi (GST-pi) in patients with unresectable non-small cell lung cancer (NSCLC) has not been established.We performed immunohistochemical staining of p53, P-gp and GST-pi using transbronchial biopsy specimens obtained from previously untreated NSCLC patients.Of 45 patients examined, p53 immunostaining was positive in 18 (40%) patients. The objective response rate by cisplatin (CDDP)-based chemotherapy was significantly lower in patients with p53-positive tumors compared to those with p53-negative tumors (22% versus 59%, p = 0.0143). Survival of the patients with p53-positive tumors was significantly shorter than those with p53-negative tumors (median survival time: 4.6 months versus 12.2 months, p = 0.011), which was confirmed by the multivariate analysis (p = 0.0243). However, P-gp and GST-pi showed no significant relationship with either response rate or survival in patients with unresectable NSCLC receiving CDDP-based chemotherapy.p53 alteration is an independent and significant indicator to predict unfavorable prognosis in patients with unresectable NSCLC.
- Okayama University Japan
Male, ATP Binding Cassette Transporter, Subfamily B, Lung Neoplasms, Biopsy, Middle Aged, Prognosis, Immunohistochemistry, Survival Rate, Carcinoma, Non-Small-Cell Lung, Antineoplastic Combined Chemotherapy Protocols, Multivariate Analysis, Mutation, Humans, Female, Cisplatin, Tumor Suppressor Protein p53, Glutathione Transferase, Retrospective Studies
Male, ATP Binding Cassette Transporter, Subfamily B, Lung Neoplasms, Biopsy, Middle Aged, Prognosis, Immunohistochemistry, Survival Rate, Carcinoma, Non-Small-Cell Lung, Antineoplastic Combined Chemotherapy Protocols, Multivariate Analysis, Mutation, Humans, Female, Cisplatin, Tumor Suppressor Protein p53, Glutathione Transferase, Retrospective Studies
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