https://pubmed.ncbi.nlm.nih.go...

Article . 2011

Data sources: Europe PubMed Central

Link to

shareShare

Cite

Select content type to embed

All Research products

arrow_drop_down

<script type="text/javascript">
<!--
document.write('<div id="oa_widget"></div>');
document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=undefined&type=result"></script>');
-->
</script>

COPY SCRIPT

For further information contact us at helpdesk@openaire.eu

[Study on expression and relationship between proliferating cell nuclear antigen and p53 oncoprotein in nasopharyngeal carcinoma].

descriptionPublicationkeyboard_double_arrow_right Article 04 Apr 2011Journal:Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology, volume 19

Authors: Qing, Cheng; Jingjing, Wei; Xiang, Huang;

pmid: 16248462

[Study on expression and relationship between proliferating cell nuclear antigen and p53 oncoprotein in nasopharyngeal carcinoma].

- Summary
- Subjects
- Related research
  (139)
- Metrics

tips_and_updates
Recommended

Abstract

To observe PCNA p53 gene expression and their relationship with clinicopathologic factors in primary nasopharyngeal carcinoma(NPC).PCNA, p53 proteins were assayed with immunohistochemical technique.The expression of p53 protein was 9.5% in chronic inflammation of nasopharyngeal epithelium(CINE), which was significantly lower than it in NPCs with 76.3% (P < 0.01). In NPCs. p53 gene expression was significantly correlated with cervical lymph node metastasis of NPCs (P < 0.01), The expression of p53 in stage II, III, lV (93.3%, 80.0% and 100% respectively) were significantly higher than that in stage I (40.0%) (P < 0.01), the expression of PCNA and p53 protein was highly correlated (P < 0.01).The expression of p53 is the useful factor in diagnosis of NPC, the overexpression of p53 is related with the stage and cervical lymph node metastasis of NPC. And PCNA PI may represent the proliferative state of NPC, all of them may play important roles in the pathogenesis of nasopharyngeal carcinoma.

Related Organizations

Union Hospital
China (People's Republic of)
Huazhong University of Science and Technology
China (People's Republic of)

Keywords

Adult, Male, Adolescent, Nasopharyngeal Neoplasms, Middle Aged, Prognosis, Young Adult, Lymphatic Metastasis, Proliferating Cell Nuclear Antigen, Humans, Female, Tumor Suppressor Protein p53, Aged, Neoplasm Staging

139 Research products, page 1 of 14

p53
2017IsRelatedTo
Cellular tumor antigen p53
2017IsRelatedTo
TP53
2017IsRelatedTo
Tumor suppressor p53
2018IsRelatedTo
Tumor protein p53
2018IsRelatedTo
Cellular tumor antigen p53
2017IsRelatedTo
Tumor supressor p53
2018IsRelatedTo
Tumor protein p53
2017IsRelatedTo
Tumor protein p53
2017IsRelatedTo
Truncated p53 splice variant
2017IsRelatedTo

chevron_left
1
2
3
4
5
chevron_right

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	0
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Average
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Average
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Average