[Expression of synaptophysin in experimental diffuse brain injury].

Name: [Expression of synaptophysin in experimental diffuse brain injury].
Keywords: Cerebral Cortex, Neurons, Time Factors, Staining and Labeling, Synaptophysin, Brain, Diffuse Axonal Injury, Immunohistochemistry, Intracranial Hemorrhage, Traumatic, Rats

descriptionPublicationkeyboard_double_arrow_right Article 02 Feb 2010Journal:Fa yi xue za zhi, volume 23 (issn: 1004-5619,

Authors: Shuan-liang, Fan; Ping, Huang; Yan-feng, Liu; Pin, Zhang; Zhen-yuan, Wang;

pmid: 17330749

[Expression of synaptophysin in experimental diffuse brain injury].

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Abstract

To investigate the changes in the expression_level of synaptophysin following diffuse brain injury (DBI) in rats and to correlate the changes of the synaptophysin expression_level with the post injury time interval.Wister rats were used as a DBI model induced by Marmarou method. The changes of synaptophysin immunoreactivity on coronal sections of the rats sampled at different post-injury time intervals were used as a marker. The densitometry of the synaptophysin immunoreactivity was documented by imaging technique and analyzed by SPSS software.The expression level of synaptophysin in DBI rats showed dynamic changes following DBI as well as during the repairing period.The changes of synaptophysin level may be used as a marker for estimation of the post injury time interval in DBI.

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Xi’an Jiaotong-Liverpool University
China (People's Republic of)

Keywords

Cerebral Cortex, Neurons, Time Factors, Staining and Labeling, Synaptophysin, Brain, Diffuse Axonal Injury, Immunohistochemistry, Intracranial Hemorrhage, Traumatic, Rats, Rats, Sprague-Dawley, Disease Models, Animal, Brain Injuries, Synapses, Animals

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