Several genetic risk factors such as single nucleotide polymorphisms(SNPs) in candidate genes have been reported to be responsible for diabetic macroangiopathy. We determined their genotypes regarding more than 100 SNPs in candidate genes responsible for average IMT of Japanese type 2 diabetic patients. We depicted some SNPs which were found to be significantly (p<0.05) responsible to the increase in AveIMT. Then, two combinations of double SNPs were evaluated as responsible for significant increases in AveIMT. Also, these two combinations were probably responsible for a high frequency of history of old myocardial infarction. The present analysis may provide one approach to evaluate combination of multiple genetic risk factors, which is synergistically associated with carotid atherosclerosis and myocardial infarction.