[Polymorphisms in XRCC1 and ERCC4/XPF DNA repair genes and associations with breast cancer risk in women].
Copyright policy )[Polymorphisms in XRCC1 and ERCC4/XPF DNA repair genes and associations with breast cancer risk in women].
Common polymorphism in DNA repair genes may alter protein function and an individual's capacity to repair damaged DNA; deficits in repair capacity may lead to genetic instability and carcinogenesis.In the present work the distribution of genotypes and frequency of alleles of the Arg194Trp and Arg399Gln polymorphism of XRCC1 and Arg415Gln polymorphism in ERCC4/XPF in subjects with breast cancer were investigated.Blood samples were obtained from 100 women with breast cancer and control (n = 106). The polymorphisms were determined by PCR-RFLP.The distribution of the genotypes of the Arg194Trp and Arg399Gln polymorphism of XRCC1 and Arg415Gln polymorphism of ERCC4/XPF 9 in both control and patients did not differ significantly (p > 0.05) from those predicted by the Hardy-Weinberg distribution. There were no significant differences (p > 0.05) in genotype distributions and allele frequencies between subgroups assigned to histological stage.The results suggest that the Arg194Trp andArg399Gln polymorphism of XRCC1 gene as well as Arg415Gln polymorphism in ERCC4/XPF may not be linked with appearance and development of breast cancer.
Adult, Polymorphism, Genetic, DNA Repair, Carcinoma, Breast Neoplasms, DNA, Middle Aged, DNA-Binding Proteins, X-ray Repair Cross Complementing Protein 1, Risk Factors, Case-Control Studies, Biomarkers, Tumor, Humans, Female, Genetic Predisposition to Disease, Breast, Polymorphism, Restriction Fragment Length, Aged
Adult, Polymorphism, Genetic, DNA Repair, Carcinoma, Breast Neoplasms, DNA, Middle Aged, DNA-Binding Proteins, X-ray Repair Cross Complementing Protein 1, Risk Factors, Case-Control Studies, Biomarkers, Tumor, Humans, Female, Genetic Predisposition to Disease, Breast, Polymorphism, Restriction Fragment Length, Aged
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).11 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Average
Citations provided by BIP!Popularity provided by BIP!