Susceptibility to Coxsackievirus B3-induced chronic myocarditis maps near the murine Tcr alpha and Myhc alpha loci on chromosome 14.

Name: Susceptibility to Coxsackievirus B3-induced chronic myocarditis maps near the murine Tcr alpha and Myhc alpha loci on chromosome 14.
Keywords: Mice, Myocarditis, Phenotype, Genetic Linkage, Chronic Disease, Animals, Chromosome Mapping, Coxsackievirus Infections, Genetic Predisposition to Disease, Mice, Inbred Strains

descriptionPublicationkeyboard_double_arrow_right Article 09 Apr 1991 English Journal:The American journal of pathology, volume 138 (issn: 0002-9440,

Authors: M D, Traystman; L H, Chow; B M, McManus; A, Herskowitz; M N, Nesbitt; K W, Beisel;

pmid: 1848043

pmc: PMC1886275

Susceptibility to Coxsackievirus B3-induced chronic myocarditis maps near the murine Tcr alpha and Myhc alpha loci on chromosome 14.

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Abstract

This study was undertaken to determine the genetic control of host susceptibility to coxsackievirus B3 (CVB3)-induced chronic myocarditis in a mouse model. An autosomal recessive autoimmune myocardial disease (amd) gene (possibly more than one gene), which determined susceptibility to CVB3-induced chronic myocarditis in the A/J and DBA/2J inbred mouse strains, was mapped to a segment of chromosome 14. Data from both the AXB/BXA recombinant inbred (RI) strains and the B10.D2(57N) H-8b congenic mice supported this linkage relationship. Analysis of the AXB/BXA RI strain distribution patterns suggested that amd maps distal to the Np-2, Tcr alpha, and Myhc alpha loci.

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University of Nebraska Medical Center
United States

Keywords

Mice, Myocarditis, Phenotype, Genetic Linkage, Chronic Disease, Animals, Chromosome Mapping, Coxsackievirus Infections, Genetic Predisposition to Disease, Mice, Inbred Strains, Autoimmune Diseases, Enterovirus B, Human

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