[Association of -63A/C polymorphism of glutathione S-transferase M3 gene with essential hypertension in Chinese population].
Copyright policy )[Association of -63A/C polymorphism of glutathione S-transferase M3 gene with essential hypertension in Chinese population].
To investigate the distribution of -63A/C polymorphism of human glutathione S-transferase M3(GSTM3) gene in Chinese Han population and the association of -63A/C polymorphism with essential hypertension (EH).-63A/C polymorphism of GSTM3 gene was examined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in 234 patients with EH and 328 healthy controls. The genotypes were confirmed partially by DNA sequencing.The distribution of GSTM3 -63A/C was in Hardy-Weinberg equilibrium. The CC genotype frequency in EH group (6%) was significantly higher than that in control group(1.8%) (P < 0.05). After adjustment for age, body mass index, and other risk factors, the CC genotype was independently associated with hypertension (OR=3.447, 95%CI: 1.19-7.63; P=0.04).The GSTM3 -63A/C polymorphism was associated with EH in Chinese Han population, the C allele might be a risk factor for EH in Chinese Han nationality.
- China Medical University China (People's Republic of)
Adult, Male, Base Sequence, Genotype, Middle Aged, Polymorphism, Single Nucleotide, Isoenzymes, Asian People, Gene Frequency, Case-Control Studies, Hypertension, Ethnicity, Humans, Regression Analysis, Female, Polymorphism, Restriction Fragment Length, Aged, Glutathione Transferase
Adult, Male, Base Sequence, Genotype, Middle Aged, Polymorphism, Single Nucleotide, Isoenzymes, Asian People, Gene Frequency, Case-Control Studies, Hypertension, Ethnicity, Humans, Regression Analysis, Female, Polymorphism, Restriction Fragment Length, Aged, Glutathione Transferase
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