[Correlative study of nuclear factor-kappa B subunit p50 activity and IL-4 gamma-IFN expression in nasal polyps].

Name: [Correlative study of nuclear factor-kappa B subunit p50 activity and IL-4 gamma-IFN expression in nasal polyps].
Keywords: Adult, Male, Interferon-gamma, Young Adult, Nasal Polyps, Adolescent, Case-Control Studies, Humans, NF-kappa B p50 Subunit, Female

descriptionPublicationkeyboard_double_arrow_right Article 16 Jun 2011Journal:Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery, volume 22 (issn: 2096-7993,

Authors: Yunqiu, Li; Yong, Feng; Jihua, Wang; Xuping, Xiao;

pmid: 18476609

[Correlative study of nuclear factor-kappa B subunit p50 activity and IL-4 gamma-IFN expression in nasal polyps].

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Abstract

To explore the possible regulation mechanism of nuclear factor-kappa B subunit p50 on Th1/Th2 cytokine in nasal polyps.The expression of IL-4, gamma-IFN and p50 were examined by the method of immunohistochemistry staining in 40 cases of nasal polyps and 20 normal subjects, and the linear correlations between activity of p50 and IL-4, gamma-IFN were evaluated.The expression of p50 mainly distribute in the cytoplasm of epithelia, inflammatory cell and the epithelia of gland. The expression of IL-4 and the activity of p50 was increased significantly in nasal polyps (all P0.05). Pearson correlation analysis demonstrated that p50 nuclear-presented closely correlation with IL-4 level, but not gamma-IFN. The correlation coefficient was 0.70 for p50 and IL-4 (P0.05).The activity of p50 in nasal polyps is increased significantly. The activation of p50 may play an important role in the imbalance of Th1/Th2-typed cytokines by upregulating the level of IL-4.

Keywords

Adult, Male, Interferon-gamma, Young Adult, Nasal Polyps, Adolescent, Case-Control Studies, Humans, NF-kappa B p50 Subunit, Female, Interleukin-4, RNA, Messenger, Middle Aged

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