Molecular cloning of the epidermal growth factor-stimulated protein kinase p56 KKIAMRE.
Copyright policy Molecular cloning of the epidermal growth factor-stimulated protein kinase p56 KKIAMRE.
A 56 kDa protein kinase was molecularly cloned from human fetal brain. This protein kinase (p56 KKIAMRE) shares homology with p42 KKIALRE (Meyerson et al., 1992) and is related to the proline-directed protein kinase group of signal transducing enzymes. The p56 KKIAMRE and p42 KKIALRE protein kinases exhibit mutually exclusive expression in reproductive tissues; p56 KKIAMRE in testis and p42 KKIALRE in ovary. p56 KKIAMRE and p42 KKIALRE may therefore contribute to signal transduction within these highly differentiated tissues. p56 KKIAMRE and p42 KKIALRE are activated by treatment of cells with epidermal growth factor (EGF). Although p56 KKIAMRE and p42 KKIALRE contain the MAP kinase dual phosphorylation motif Thr-Xaa-Tyr (Thr-Asp-Tyr), phosphorylation on Thr and Tyr within this motif is not required for EGF-stimulated protein kinase activity.
- University of Massachusetts Medical School United States
Mitogen-Activated Protein Kinase Kinases, Base Sequence, Epidermal Growth Factor, Sequence Homology, Amino Acid, Molecular Sequence Data, MAP Kinase Kinase 1, Sequence Analysis, DNA, Protein Serine-Threonine Kinases, Protein-Tyrosine Kinases, Blotting, Northern, Cyclin-Dependent Kinases, Substrate Specificity, COS Cells, Calcium-Calmodulin-Dependent Protein Kinases, Animals, Humans, Amino Acid Sequence, Cloning, Molecular, Phosphorylation
Mitogen-Activated Protein Kinase Kinases, Base Sequence, Epidermal Growth Factor, Sequence Homology, Amino Acid, Molecular Sequence Data, MAP Kinase Kinase 1, Sequence Analysis, DNA, Protein Serine-Threonine Kinases, Protein-Tyrosine Kinases, Blotting, Northern, Cyclin-Dependent Kinases, Substrate Specificity, COS Cells, Calcium-Calmodulin-Dependent Protein Kinases, Animals, Humans, Amino Acid Sequence, Cloning, Molecular, Phosphorylation
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