[Effects of Rb1 and Rg1 on the expression of Bcl-2, Bax in apoptosis of HK-2 cells induced by the serum of kidney ischemia/reperfusion].
Copyright policy )[Effects of Rb1 and Rg1 on the expression of Bcl-2, Bax in apoptosis of HK-2 cells induced by the serum of kidney ischemia/reperfusion].
To explore effects of Ginsenosides (Rb1, Rg1) on the expression of Bcl-2, Bax in the serum of kidney ischemia/reperfusion inducing apoptosis of HK-2 cells.The serum of rabbits with renal ischemia/reperfusion (SIR) and the control serum of rabbits (SC) were acquired and cultured with HK-2 cells. Detected apoptosis with TUNEL assay. The experiment was designed as: control group,ischemia/ reperfusion group, Rb1 blocking group and Rg1 blocking group. To detect the expression of Bcl-2, Bax with immunocytochemistry after 24 hours' cultured.The expression of Bax in Rb1 blocking group and Rg1 blocking group were significantly decreased (P < 0.01), the ratios of Bcl-2/Bax were increased as compared with ischemia/reperfusion group.Rb1 and Rg1 have protective effects on apoptosis of HK-2 cells induced by serum of kidney ischemia/reperfusion.
Male, Serum, Ginsenosides, Apoptosis, Kidney, Cell Line, Kidney Tubules, Proximal, Proto-Oncogene Proteins c-bcl-2, Ischemia, Reperfusion Injury, Animals, Female, Rabbits, bcl-2-Associated X Protein
Male, Serum, Ginsenosides, Apoptosis, Kidney, Cell Line, Kidney Tubules, Proximal, Proto-Oncogene Proteins c-bcl-2, Ischemia, Reperfusion Injury, Animals, Female, Rabbits, bcl-2-Associated X Protein
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