Haematologica

Article . 2006

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The frequency of HLA class I alleles in Japanese patients with bone marrow failure.

descriptionPublicationkeyboard_double_arrow_right Article 05 Oct 2006 English Journal:Haematologica, volume 91 (issn: 1592-8721,

Authors: Tsutomu, Shichishima; Hideyoshi, Noji; Kazuhiko, Ikeda; Kazuko, Akutsu; Yukio, Maruyama;

pmid: 16704965

The frequency of HLA class I alleles in Japanese patients with bone marrow failure.

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Abstract

The frequencies of the HLA-B*4002 and HLA-A*0206 alleles in patients with aplastic anemia (AA) (n=32; 21.9%) and paroxysmal nocturanl hemoglobinuria (PNH) (n=24; 22.9%), respectively, were significantly different from those in controls (n=371; 8.6%, p<0.002 and 7.7%, p<0.001, respectively), suggesting that each specific allele in AA or PNH may be related to the immunologic pathophysiology of these disorders.

Keywords

Gene Frequency, Japan, Histocompatibility Antigens Class I, Hemoglobinuria, Paroxysmal, Anemia, Aplastic, Humans, Treatment Failure, Bone Marrow Transplantation

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MHC class I antigen
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MHC class I human leukocyte antigen
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