[Expression of MDR1 and KIT in imatinib-resistant gastrointestinal stromal tumor cells].
Copyright policy )[Expression of MDR1 and KIT in imatinib-resistant gastrointestinal stromal tumor cells].
To explore the relationship between imatinib resistance and genes MDR1 and KIT in gastrointestinal stromal tumor (GIST) cells.The MDR1 and KIT mRNA level in GIST882-R and GIST882-S cells were detected by RT-PCR. Immunocytochemistry and Western blot were employed to detect P-gp and CD117 expression in GIST882-R and GIST882-S cells.The relative expression of MDR1 mRNA was 0.321 + or - 0.033 in GIST882-R and 0.157 + or - 0.056 in GIST882-S cells, and the difference was statistically significant (P0.05). The relative density of P-gp was 0.443 + or - 0.058 in GIST882-R and 0.237 + or - 0.094 in GIST882-S, and the difference was statistically significant (P0.05).Over-expression of gene MDR1 may be associated with imatinib resistance in GIST. KIT may not be involved in imatinib resistance.
- Fudan University China (People's Republic of)
- Zhongshan Hospital China (People's Republic of)
Proto-Oncogene Proteins c-kit, Pyrimidines, Drug Resistance, Neoplasm, Gastrointestinal Stromal Tumors, Cell Line, Tumor, Benzamides, Imatinib Mesylate, Humans, ATP Binding Cassette Transporter, Subfamily B, Member 1, Cell Adhesion Molecules, Protein Kinase Inhibitors, Piperazines
Proto-Oncogene Proteins c-kit, Pyrimidines, Drug Resistance, Neoplasm, Gastrointestinal Stromal Tumors, Cell Line, Tumor, Benzamides, Imatinib Mesylate, Humans, ATP Binding Cassette Transporter, Subfamily B, Member 1, Cell Adhesion Molecules, Protein Kinase Inhibitors, Piperazines
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