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[Significance of beta-catenin and Cyclin D1 express in glioma].

descriptionPublicationkeyboard_double_arrow_right Article 10 Mar 2010Journal:Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology, volume 25 (issn: 1007-8738,

Authors: Zhi-qiang, Zhang; Hong-qing, Chen; Ying-hong, Chen; Xin-fu, Cheng;

pmid: 19900369

[Significance of beta-catenin and Cyclin D1 express in glioma].

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Abstract

To investigate the expression and the significance of beta-catenin and Cyclin D1 in gliomas.The SABC immunohistochemistry were used to detect the expression of beta-catenin and Cyclin D1 in 49 brain gliomas and 5 normal brain tissues.The beta-catenin positive ratio in normal brain tissues and glioma samples are 2/5 and 38/49(P<0.01) respectively, and the Cyclin D1 positive ratio in normal brain tissues and gliomas are 1/5 and 42/49(P<0.01); Compared with the normal brain tissue, both the immunohistochemical expression of beta-catenin and Cyclin D1 were up-regulated(P<0.05), and the expression of beta-catenin and Cyclin D1 between the normal brain tissues and gliomas exhibited significantly difference (P<0.01).beta-catenin and Cyclin D1 increased in gliomas may be precipitate the tumorigenesis of glioma.

Keywords

Adult, Cell Nucleus, Male, Adolescent, Glioma, Middle Aged, Immunohistochemistry, Up-Regulation, Gene Expression Regulation, Neoplastic, Young Adult, Humans, Cyclin D1, Female, Child, beta Catenin, Aged

14 Research products, page 1 of 2

Cyclin D1
2017IsRelatedTo
Cyclin N-terminal domain-containing protein
2017IsRelatedTo
cDNA FLJ59565, highly similar to Beta-catenin
2017IsRelatedTo
Beta-catenin
2017IsRelatedTo
Catenin (Cadherin-associated protein), beta 1, 88kDa, isoform CRA_a
2017IsRelatedTo
Cadherin-associated protein
2017IsRelatedTo
Catenin beta-1
2017IsRelatedTo
Cyclin D1
2017IsRelatedTo
cDNA FLJ51281, highly similar to G1/S-specific cyclin-D1
2017IsRelatedTo
Catenin beta-1
2017IsRelatedTo

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