DC-SIGN; a related gene, DC-SIGNR; and CD23 form a cluster on 19p13.
Copyright policy )DC-SIGN; a related gene, DC-SIGNR; and CD23 form a cluster on 19p13.
DC-SIGN is a C-type lectin, expressed on a dendritic cell subset. It is able to bind ICAM3 and HIV gp120 in a calcium-dependent manner. Here we report the genomic organization of DC-SIGN and map it to chromosome 19p13 adjacent to the C-type lectin CD23 (FcepsilonRII). We also report a novel, closely linked gene, DC-SIGNR, which shows 73% identity to DC-SIGN at the nucleic acid level and a similar genomic organization. Proteins encoded by both genes have tracts of repeats of 23 aa, predicted to form a coiled coil neck region. They also possess motifs that are known to bind mannose in a calcium-dependent fashion. We show concomitant expression of the two genes in endometrium, placenta, and stimulated KG1 cells (phenotypically similar to monocyte-derived dendritic cells). The existence of a DC-SIGN-related gene calls for reinterpretation of the HIV data to consider possible DC-SIGN/DC-SIGNR hetero-oligomerization.
- University of Cambridge United Kingdom
DNA, Complementary, Genetic Linkage, Receptors, IgE, Molecular Sequence Data, Chromosome Mapping, Gene Expression, Receptors, Cell Surface, Dendritic Cells, Exons, Introns, Cell Line, Organ Specificity, Lectins, Multigene Family, Humans, Lectins, C-Type, Amino Acid Sequence, Cloning, Molecular, Cell Adhesion Molecules, Chromosomes, Human, Pair 19
DNA, Complementary, Genetic Linkage, Receptors, IgE, Molecular Sequence Data, Chromosome Mapping, Gene Expression, Receptors, Cell Surface, Dendritic Cells, Exons, Introns, Cell Line, Organ Specificity, Lectins, Multigene Family, Humans, Lectins, C-Type, Amino Acid Sequence, Cloning, Molecular, Cell Adhesion Molecules, Chromosomes, Human, Pair 19
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