A novel protein phosphatase 2C family member (PP2Czeta) is able to associate with ubiquitin conjugating enzyme 9.
Copyright policy )A novel protein phosphatase 2C family member (PP2Czeta) is able to associate with ubiquitin conjugating enzyme 9.
In this study we have cloned a novel member of mouse protein phosphatase 2C family, PP2Czeta, which is composed of 507 amino acids and has a unique N-terminal region. The overall similarity of the amino acid sequence between PP2Czeta and PP2Calpha was 22%. On Northern blot analysis PP2Czeta was found to be expressed specifically in the testicular germ cells. PP2Czeta expressed in COS7 cells was able to associate with ubiquitin conjugating enzyme 9 (UBC9) and the association was enhanced by co-expression of small ubiquitin-related modifier-1 (SUMO-1), suggesting that PP2Czeta exhibits its specific role through its SUMO-induced recruitment to UBC9.
- Tohoku University Japan
DNA, Complementary, Base Sequence, Sequence Homology, Amino Acid, Ubiquitin-Conjugating Enzyme UBC9, Molecular Sequence Data, Blotting, Northern, Recombinant Proteins, Isoenzymes, Ligases, Protein Phosphatase 2C, COS Cells, Ubiquitin-Conjugating Enzymes, Escherichia coli, Phosphoprotein Phosphatases, Animals, Amino Acid Sequence, Protein Binding
DNA, Complementary, Base Sequence, Sequence Homology, Amino Acid, Ubiquitin-Conjugating Enzyme UBC9, Molecular Sequence Data, Blotting, Northern, Recombinant Proteins, Isoenzymes, Ligases, Protein Phosphatase 2C, COS Cells, Ubiquitin-Conjugating Enzymes, Escherichia coli, Phosphoprotein Phosphatases, Animals, Amino Acid Sequence, Protein Binding
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