Haematologica

Article . 2006

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Homozygosity of the T allele of the 46 C-->T polymorphism in the F12 gene is a risk factor for acute coronary artery disease in the Spanish population.

descriptionPublicationkeyboard_double_arrow_right Article 17 May 2006 English Journal:Haematologica, volume 89 (issn: 1592-8721,

Authors: Amparo, Santamaría; Antonio, Martínez-Rubio; José, Mateo; Isabel, Tirado; José M, Soria; Jordi, Fontcuberta;

pmid: 15257949

Homozygosity of the T allele of the 46 C-->T polymorphism in the F12 gene is a risk factor for acute coronary artery disease in the Spanish population.

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Abstract

Following new guidelines that contain recommendations on the desirable features of a genetic association study, we performed a case-control study to establish the risk of acute coronary artery disease (CAD) related to the polymorphism (46 C-->T) in the F12 gene. We found a 6-fold higher risk of acute CAD associated with the homozygosity of the T allele of the F12, 46C-->T polymorphism in the Spanish population.

Keywords

Adult, Male, Polymorphism, Genetic, Homozygote, Coronary Artery Disease, Middle Aged, Risk Factors, Spain, Acute Disease, Factor XII, Humans, Female, Genetic Predisposition to Disease, Aged

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