Association of HLA-B alleles with human immunodeficiency virus type 1 infection in the Yi ethnic group in Sichuan province.
Copyright policy )Association of HLA-B alleles with human immunodeficiency virus type 1 infection in the Yi ethnic group in Sichuan province.
To determine the distribution of HLA-B alleles in the Chinese Yi ethnic group and its association with HIV infection.One hundred and six unrelated healthy HIV negative and 73 HIV positive Chinese Yi ethnic individuals were typed by PCR-SSP.The frequency of alleles B*07, Bx 35, and B*46 were increased in HIV-1-positive subjects, whereas the alleles B*55, B*44 and B*78 were absent in the HIV-infected persons studied. The B*46 allele was present in a significantly higher gene frequency among HIV-1-positive individuals (P=0.02, OR=3.32, 95% CI=1.13-9.78) compared with control subjects.HLA-B*46 may be associated with its susceptibility to HIV-1 infections.
China, Genotype, HIV Infections, DNA, Polymerase Chain Reaction, Gene Frequency, HLA-B Antigens, Case-Control Studies, Surveys and Questionnaires, HIV Seropositivity, Ethnicity, HIV-1, Humans, Genetic Predisposition to Disease
China, Genotype, HIV Infections, DNA, Polymerase Chain Reaction, Gene Frequency, HLA-B Antigens, Case-Control Studies, Surveys and Questionnaires, HIV Seropositivity, Ethnicity, HIV-1, Humans, Genetic Predisposition to Disease
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