Current Biology

Article . 2000

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How cholesterol modulates the signal.

Name: How cholesterol modulates the signal.
Creator: P W, Ingham
Keywords: 0301 basic medicine, 0303 health sciences, Binding, Competitive, Models, Biological, 3. Good health, 03 medical and health sciences, Cholesterol, Animals, Drosophila Proteins, Insect Proteins

descriptionPublicationkeyboard_double_arrow_right Article 11 Apr 2000 English Journal:Current biology : CB, volume 10 (issn: 0960-9822,

Authors: P W, Ingham;

pmid: 10712894

How cholesterol modulates the signal.

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Abstract

By coupling to cholesterol, Hedgehog can be anchored to the cells where it is made, yet to act as a morphogen, it must be able to move away from its source. Novel genes have now been identified that control the release and dispersal of Hedgehog, shedding new light on the part played by cholesterol in these processes.

Related Organizations

University of Sheffield
United Kingdom

Keywords

Binding, Competitive, Models, Biological, Cholesterol, Animals, Drosophila Proteins, Insect Proteins, Wings, Animal, Drosophila, Hedgehog Proteins, Proteoglycans, Signal Transduction

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	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	27
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 10%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%