TAPASIN, DAXX, RGL2, HKE2 and four new genes (BING 1, 3 to 5) form a dense cluster at the centromeric end of the MHC.
Copyright policy )TAPASIN, DAXX, RGL2, HKE2 and four new genes (BING 1, 3 to 5) form a dense cluster at the centromeric end of the MHC.
TAPASIN, a gene recently shown to be required for antigen presentation through MHC class I molecules, is located 180 kbp centromeric of HLA-DP in a region linked to several diseases, and associated with altered developmental phenotypes in the mouse. We present the genomic analysis of a 70 kbp gene-dense segment flanking the TAPASIN locus, including sequence, structure and preliminary characterisation of seven additional genes. BING1 is a Zn finger gene containing a POZ motif. BING3 is similar to myosin regulatory light chain. BING4 shows homologies only to hypothetical yeast and Caenorhabditis elegans proteins. BING5 is found within an intron of BING4 on the complementary strand, and encodes a molecule with no homologies to database proteins. Another three genes were identified whose full sequence was not previously known; namely, RGL2, DAXX (BING2) and HKE2. RGL2 encodes an effector of Ras, homologous to the mouse RalGDS protein, Rlf. DAXX encodes an effector of Fas that stimulates apoptosis through the Jun kinase (JNK) pathway. The location of DAXX is of interest given the linkage of autoimmune disease to the MHC and to apoptosis.
Antigen Presentation, Base Composition, DNA, Complementary, Base Sequence, Centromere, Histocompatibility Antigens Class I, Intracellular Signaling Peptides and Proteins, Immunoglobulins, Antiporters, DNA-Binding Proteins, GTP-Binding Proteins, Animals, Guanine Nucleotide Exchange Factors, Humans, Amino Acid Sequence, Cloning, Molecular, Carrier Proteins, Co-Repressor Proteins, Adaptor Proteins, Signal Transducing, DNA Primers
Antigen Presentation, Base Composition, DNA, Complementary, Base Sequence, Centromere, Histocompatibility Antigens Class I, Intracellular Signaling Peptides and Proteins, Immunoglobulins, Antiporters, DNA-Binding Proteins, GTP-Binding Proteins, Animals, Guanine Nucleotide Exchange Factors, Humans, Amino Acid Sequence, Cloning, Molecular, Carrier Proteins, Co-Repressor Proteins, Adaptor Proteins, Signal Transducing, DNA Primers
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).51 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!