2B4(CD244)-mediated activation of NK cells reduces metastases of B16F10 melanoma in mice.
Copyright policy )2B4(CD244)-mediated activation of NK cells reduces metastases of B16F10 melanoma in mice.
Natural killer (NK) cells are a third population of lymphocytes that can kill certain tumor cells. This killing is regulated by signals received through activating and inhibitory receptors. 2B4 (CD244), a member of the CD2 subset of Immunoglobulin superfamily, was identified as an activating receptor on NK cells. Interaction of 2B4 with its ligand CD48 or anti-2B4 mAb stimulates NK cell cytolytic function as well as production of INF-gamma.A murine tumor model was used to study the in vivo role of 2B4. 2B4 and CD48 were activated in vivo by injecting anti-2B4 and anti-CD48 monoclonal antibodies.Activation of 2B4 or CD48 resulted in a five-fold reduction in tumor metastasis. IFN-gamma knockout mice had a two-fold increase in metastasis as compared to wild-type after 2B4 activation.Activation of 2B4 and CD48 reduces metastasis of B16F10 melanoma cells and this anti-tumor effect involves both cytolytic function and cytokine production.
- University of North Texas Health Science Center United States
Mice, Knockout, Membrane Glycoproteins, Melanoma, Experimental, Lymphocyte Activation, Killer Cells, Natural, Mice, Inbred C57BL, Interferon-gamma, Mice, CD28 Antigens, Antigens, CD, Signaling Lymphocytic Activation Molecule Family, Animals, Receptors, Immunologic
Mice, Knockout, Membrane Glycoproteins, Melanoma, Experimental, Lymphocyte Activation, Killer Cells, Natural, Mice, Inbred C57BL, Interferon-gamma, Mice, CD28 Antigens, Antigens, CD, Signaling Lymphocytic Activation Molecule Family, Animals, Receptors, Immunologic
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