Correlation of ANXA1 expression with drug resistance and relapse in bladder cancer.
Copyright policy )Correlation of ANXA1 expression with drug resistance and relapse in bladder cancer.
To investigate the expression of annexin a1 (ANXA1) in adriamycin-resistant human bladder cancer cell line (pumc-91/ADM) compared with the parental cell line (pumc-91) and its relevance to the drug resistance of bladder cancer, as well as explore the relevance of ANXA1 in recurrent bladder cancer tissues as pertinent to relapse.qRT-PCR and Western blot were implemented to research the level of ANXA1 in two cell lines (pumc-91/ADM and pumc-91). Immunohistochemistry was applied to explore ANXA1 expression in bladder cancer tissues of different intervals of relapse. The association of ANXA1 with clinicopathological parameters was analyzed.The expression of ANXA1 was downregulated in drug-resistant cell line pumc-91/ADM compared to pumc-91. The bladder cancer tissues recurring two years later exhibited higher ANXA1 levels. ANXA1 expression level was positively correlated with T stage, while it was not connected with histological grade strongly. The expression level and influencing factors of ANXA1 in recurrent tissues of bladder cancer were clarified for the first time.ANXA1 may become a promising marker to predict the recurrence and drug resistance of bladder cancer and provide guidance for surveillance.
- Beijing Luhe Hospital Affiliated to Capital Medical University China (People's Republic of)
- Beijing Shijitan Hospital China (People's Republic of)
Male, Antibiotics, Antineoplastic, Time Factors, Down-Regulation, Middle Aged, Gene Expression Regulation, Neoplastic, Treatment Outcome, Urinary Bladder Neoplasms, Doxorubicin, Drug Resistance, Neoplasm, Risk Factors, Cell Line, Tumor, Biomarkers, Tumor, Humans, Female, Neoplasm Recurrence, Local, Annexin A1, Neoplasm Staging
Male, Antibiotics, Antineoplastic, Time Factors, Down-Regulation, Middle Aged, Gene Expression Regulation, Neoplastic, Treatment Outcome, Urinary Bladder Neoplasms, Doxorubicin, Drug Resistance, Neoplasm, Risk Factors, Cell Line, Tumor, Biomarkers, Tumor, Humans, Female, Neoplasm Recurrence, Local, Annexin A1, Neoplasm Staging
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