[Clinical significance of the expression of p53, p63 and p73 in nasal and paranasal sinus carcinoma].
Copyright policy )[Clinical significance of the expression of p53, p63 and p73 in nasal and paranasal sinus carcinoma].
To study the clinical significance of the expression of p53, p63 and p73 protein and the correlation of p53 and p63 in nasal and paranasal sinus carcinoma (NPSC).The immunohistochemical technique was used to detect the expression of p53, p63 and p73 in 67 cases of NPSC, para-cancer tissues and non-cancer tissues.The positive rate of p53 and p63 protein in NPSC was significantly higher than that in park cancer tissues and non-cancer tissues (P0.05).There are positive correlation between p53 and p63 protein in NPSC, and they may play an important role in the tumorgenesis of NPSC. The p73 may not be associated with tumorgenesis of NPSC.
- First Affiliated Hospital of Jinan University China (People's Republic of)
Male, Tumor Suppressor Proteins, Nose Neoplasms, Nuclear Proteins, Tumor Protein p73, Middle Aged, DNA-Binding Proteins, Carcinoma, Squamous Cell, Trans-Activators, Humans, Female, Tumor Suppressor Protein p53, Paranasal Sinus Neoplasms, Transcription Factors
Male, Tumor Suppressor Proteins, Nose Neoplasms, Nuclear Proteins, Tumor Protein p73, Middle Aged, DNA-Binding Proteins, Carcinoma, Squamous Cell, Trans-Activators, Humans, Female, Tumor Suppressor Protein p53, Paranasal Sinus Neoplasms, Transcription Factors
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