Russian Journal of Occupational Health and Industrial Ecology

Article . 2014

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[Genotype-phenotype characteristics of biochemical markers of endothelial dysfunction in patients with chronic mercury intoxication].

Name: [Genotype-phenotype characteristics of biochemical markers of endothelial dysfunction in patients with chronic mercury intoxication].
Keywords: Male, Polymorphism, Genetic, Endothelin-1, Genotype, Nitric Oxide Synthase Type III, Middle Aged, Nitric Oxide, Occupational Diseases, Phenotype, Occupational Exposure

descriptionPublicationkeyboard_double_arrow_right Article 26 Aug 2014 Russian Journal:Meditsina truda i promyshlennaia ekologiia (issn: 1026-9428,

Authors: O V, Popkova; I V, Kudaeva; L B, Masnavieva; V P, Belik;

pmid: 25051669

[Genotype-phenotype characteristics of biochemical markers of endothelial dysfunction in patients with chronic mercury intoxication].

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Abstract

The paper presents data on the frequency of polymorphisms of candidate genes involved in the formation of endothelial dysfunction--endothelin-1 (EDN1 Lys198Asn) and endothelial nitric oxide synthase (NOS3 T786C) together with the concentrations of their active products (nitric oxide, endothelin-1) in individuals with chronic mercury intoxication. The concentration change of nitric oxide and endothelin-1 indicates the presence of endothelial dysfunction in the individuals examined. The studied polymorphisms appeared to play a minor role in the pathogenesis of endothelial dysfunction in patients with chronic mercury intoxication.

Keywords

Male, Polymorphism, Genetic, Endothelin-1, Genotype, Nitric Oxide Synthase Type III, Middle Aged, Nitric Oxide, Occupational Diseases, Phenotype, Occupational Exposure, Chronic Disease, Mercury Poisoning, Humans, Endothelium, Biomarkers

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