The Journal of Clinical Investigation

Article . 2006

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Structure and function of the platelet integrin alphaIIbbeta3.

Name: Structure and function of the platelet integrin alphaIIbbeta3.
Creator: Joel S, Bennett
Keywords: Blood Platelets, Cytoplasm, Sequence Homology, Amino Acid, Cell Membrane, Cryoelectron Microscopy, Molecular Sequence Data, Platelet Glycoprotein GPIIb-IIIa Complex, Crystallography, X-Ray, Ligands, Models, Biological

descriptionPublicationkeyboard_double_arrow_right Article 06 Feb 2006 English Journal:The Journal of clinical investigation, volume 115 (issn: 0021-9738,

Authors: Joel S, Bennett;

pmid: 16322781

pmc: PMC1297263

Structure and function of the platelet integrin alphaIIbbeta3.

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Abstract

The platelet integrin alpha(IIb)beta(3) is required for platelet aggregation. Like other integrins, alpha(IIb)beta(3) resides on cell surfaces in an equilibrium between inactive and active conformations. Recent experiments suggest that the shift between these conformations involves a global reorganization of the alpha(IIb)beta(3) molecule and disruption of constraints imposed by the heteromeric association of the alpha(IIb) and beta(3) transmembrane and cytoplasmic domains. The biochemical, biophysical, and ultrastructural results that support this conclusion are discussed in this Review.

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University of Pennsylvania
United States

Keywords

Blood Platelets, Cytoplasm, Sequence Homology, Amino Acid, Cell Membrane, Cryoelectron Microscopy, Molecular Sequence Data, Platelet Glycoprotein GPIIb-IIIa Complex, Crystallography, X-Ray, Ligands, Models, Biological, Protein Structure, Tertiary, Structure-Activity Relationship, Animals, Humans, Amino Acid Sequence, Dimerization, Protein Binding

24 Research products, page 1 of 3

Truncated CD61
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Truncated CD61
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Platelet glycoprotein IIb
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Integrin beta
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Platelet glycoprotein IIIa
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cDNA FLJ56496, highly similar to Integrin alpha-IIb
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Integrin alpha-IIb
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Platelet glycoprotein IIIa
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Integrin subunit aIIb
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Platelet glycoprotein IIIa
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