[Synthetic and biological activity of 25R and 25S diastereoisomers of dihydroxy-25,26 cholecalciferol (25,25(OH)2D3)].
[Synthetic and biological activity of 25R and 25S diastereoisomers of dihydroxy-25,26 cholecalciferol (25,25(OH)2D3)].
The separation of 5-cholestene-3 beta, 25 (RS), 25-triol 3,26-diacetate into the diastereoisomers 25R and 25S by means of high pressure liquid chromatography (HPLC) is described. Their absolute configuration cannot be yet established. The less polar diastereoisomer is arbitrarily called 25 zeta1 and the more polar one 25 zeta2. Bromination, dehydrobromination and ultraviolet irradiation conducted to 25 zeta1, 26(OH2D3 and 25 zeta2, 26(OH)2D3 respectively. Their biological activity is described.
Male, Structure-Activity Relationship, Magnetic Resonance Spectroscopy, Hydroxycholecalciferols, Dihydroxycholecalciferols, Animals, Calcium, Stereoisomerism, Bone and Bones, Rats
Male, Structure-Activity Relationship, Magnetic Resonance Spectroscopy, Hydroxycholecalciferols, Dihydroxycholecalciferols, Animals, Calcium, Stereoisomerism, Bone and Bones, Rats
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