Identification of a novel HLA-Cw*07 variant (Cw*0714) in a German Caucasian family.
Copyright policy )Identification of a novel HLA-Cw*07 variant (Cw*0714) in a German Caucasian family.
We report herein the identification of a new HLA-Cw*07 allele in two members of a German Caucasian family. This novel allele, designated as Cw*0714, differs from Cw*07011 and Cw*0706 by two nucleotide changes: one at codon 66 (AAC-->AAG) in the exon 2, leading to an amino acid change from Asn to Lys; and another silent substitution at codon 99 (TAT-->TAC) in the exon 3. The latest substitution (T-->C at the third position of codon 99) was not seen in any of the HLA-Cw*07 alleles reported so far, thus being characteristic to the new HLA-Cw*0714 allele.
Male, Base Sequence, Histocompatibility Testing, Molecular Sequence Data, HLA-C Antigens, Sequence Analysis, DNA, White People, Sequence Homology, Nucleic Acid, Humans, Point Mutation, Amino Acid Sequence, Alleles
Male, Base Sequence, Histocompatibility Testing, Molecular Sequence Data, HLA-C Antigens, Sequence Analysis, DNA, White People, Sequence Homology, Nucleic Acid, Humans, Point Mutation, Amino Acid Sequence, Alleles
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