[Ultrastructure and crystallin mutant molecular modeling of hereditary coralliform cataract].

descriptionPublicationkeyboard_double_arrow_right Article 15 Nov 2005Journal:Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences, volume 34 (issn: 1008-9292,

Authors: Wei-zhen, Xu; Shu, Zheng; Qi, Dong; Shan-rong, Cai; Ke, Yao; Su-zhan, Zhang;

pmid: 15940793

[Ultrastructure and crystallin mutant molecular modeling of hereditary coralliform cataract].

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Abstract

To observe the correlation of gammaD-crystallin P23T mutant with lens ultrastructure of the hereditary coralliform cataract.Complete ophthalmologic examinations were performed before lens extraction and lens samples were studied by transmission and scanning electric microscope respectively. Protein molecular modeling was performed using SWISS-MODEL(version 2.0).Protein structure modeling demonstrated that the mutant caused a decrease in molecular final total energy and changes in the surface structure of gammaD-crystallin. Ultrastructure study revealed crystals deposited in lens, extensive granules dispersed in uncommon oval structure and the disorganization of lens epithelial cells.It is possible that the gammaD-crystallin P23T mutant is associated with abnormal crystals in lens and disorganization of lens epithelial cells.

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Zhejiang Ocean University
China (People's Republic of)

Keywords

Male, Phenotype, Lens, Crystalline, Humans, Point Mutation, Female, gamma-Crystallins, Cataract, Pedigree

16 Research products, page 1 of 2

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