[The bHLH TAL1 protein: a key molecule in the hematopoietic and endothelial systems].
Copyright policy )[The bHLH TAL1 protein: a key molecule in the hematopoietic and endothelial systems].
The formation of blood cells and vascular networks occurs simultaneously during development, and both lineages remain in close association in all adult tissues. The functional setting of both systems within the embryo and their renewal during adult life are highly complex processes, and require the involvement of numerous molecular actors, the activities of which are often overlapping. Here, I review the activity of TAL-1, a basic-helix-loop-helix transcription factor, which plays a key role in the formation and functioning of both blood and endothelial systems, with a particular emphasis on recent data that associate TAL-1 with angiogenesis.
Adult, Mice, Knockout, Models, Molecular, Hematopoietic System, Molecular Sequence Data, Gene Expression Regulation, Developmental, Neovascularization, Physiologic, LIM Domain Proteins, Cadherins, DNA-Binding Proteins, Mice, Antigens, CD, Multiprotein Complexes, Metalloproteins, Basic Helix-Loop-Helix Transcription Factors, Animals, Humans, Amino Acid Sequence, Endothelium, Vascular, Adaptor Proteins, Signal Transducing
Adult, Mice, Knockout, Models, Molecular, Hematopoietic System, Molecular Sequence Data, Gene Expression Regulation, Developmental, Neovascularization, Physiologic, LIM Domain Proteins, Cadherins, DNA-Binding Proteins, Mice, Antigens, CD, Multiprotein Complexes, Metalloproteins, Basic Helix-Loop-Helix Transcription Factors, Animals, Humans, Amino Acid Sequence, Endothelium, Vascular, Adaptor Proteins, Signal Transducing
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