Screening for ZNF230 gene mutation and analysis of its correlation with azoospermia.
Copyright policy )Screening for ZNF230 gene mutation and analysis of its correlation with azoospermia.
To investigate the possible association between ZNF230 gene and azoospermia.Screening for mutation of all 6 exons of ZNF230 gene was performed by denaturing high performance liquid chromatography(DHPLC) in 99 patients with azoospermia and in 115 healthy men as controls.An A-->G transition at nucleotide 316 in exon 6 was identified. There were significant differences in the distribution profiles of both allele and genotype frequencies between patient group and control group (P < 0.01 and P < 0.05, respectively). In addition,there was a statistically significant difference in the serum follicle stimulating hormone (FSH) level between the patients with GG/GA genotype and those with AA genotype (P < 0.05).ZNF230 gene may be associated with azoospermia, and the A316G mutation may be correlated with the serum FSH level.
- Sichuan University China (People's Republic of)
Adult, Male, Base Sequence, Genotype, DNA Mutational Analysis, Polymerase Chain Reaction, DNA-Binding Proteins, Young Adult, Gene Frequency, Mutation, Humans, Genetic Testing, Chromatography, High Pressure Liquid, Azoospermia, Transcription Factors
Adult, Male, Base Sequence, Genotype, DNA Mutational Analysis, Polymerase Chain Reaction, DNA-Binding Proteins, Young Adult, Gene Frequency, Mutation, Humans, Genetic Testing, Chromatography, High Pressure Liquid, Azoospermia, Transcription Factors
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