[Expression and clinical significance of calcium-activated chloride channel and mucins in nasal mucosa with allergic rhinitis].
Copyright policy )[Expression and clinical significance of calcium-activated chloride channel and mucins in nasal mucosa with allergic rhinitis].
To evaluate the role of human calcium-activated chloride channel 1 (hCLCA1) and mucin MUC5AC in allergic rhinitis.The expression of hCLCA1 and MUC5AC were determined by RT-PCR and immunohistochemical assay in nasal mucosa on 20 patients with allergic rhinitis and 7 normal persons.The expression of hCLCA1mRNA in allergic rhinitis group was positive, whereas in normal control group was absent (P<0.01). The expression of MUC5AC mRNA and MUC5AC protein in the allergic rhinitis group were higher than that in the control, respectively (both P<0.01). The increased expression of hCLCA1mRNA in allergic rhinitis group were well correlated with the expression of MUC5ACmRNA and MUC5AC protein and the correlation coefficients were 0.752 and 0.694(both P<0.05).Upregulation of hCLCA1 mRNA expression may play a pivotal role in mucus overproduction in allergic rhinitis group. The inhibition of HCLCA1 expression may provide a new strategy for the treatment of allergic rhinitis.
- Huazhong University of Science and Technology China (People's Republic of)
- Tongji Hospital China (People's Republic of)
Adult, Male, Rhinitis, Allergic, Perennial, Adolescent, Middle Aged, Mucin 5AC, Nasal Mucosa, Young Adult, Chloride Channels, Humans, Female
Adult, Male, Rhinitis, Allergic, Perennial, Adolescent, Middle Aged, Mucin 5AC, Nasal Mucosa, Young Adult, Chloride Channels, Humans, Female
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).0 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Average
Citations provided by BIP!Popularity provided by BIP!