Association between survival after treatment for breast cancer and glutathione S-transferase P1 Ile105Val polymorphism.
Copyright policy )Association between survival after treatment for breast cancer and glutathione S-transferase P1 Ile105Val polymorphism.
A glutathione S-transferase (GST) P1 polymorphism results in an amino acid substitution, Ile105Val; the Val-containing enzyme has reduced activity toward alkylating agents. Cancer patients with the variant enzyme may differ in removal of treatment agents and in outcomes of therapy. We evaluated survival according to GSTP1 genotype among women (n = 240) treated for breast cancer. Women with the low-activity Val/Val genotype had better survival. Compared with Ile/Ile, hazard ratios for overall survival were 0.8 (95% confidence interval, 0.5-1.3) for Ile/Val and 0.3 (95% confidence interval, 0.1-1.0) for Val/Val (P for trend = 0.04). Inherited metabolic variability may influence treatment outcomes.
- United States Food and Drug Administration United States
- National Center for Toxicological Research United States
Adult, Polymorphism, Genetic, Genotype, Breast Neoplasms, Valine, Middle Aged, Survival Analysis, Disease-Free Survival, Isoenzymes, Treatment Outcome, Amino Acid Substitution, Glutathione S-Transferase pi, Receptors, Estrogen, Humans, Female, Isoleucine, Aged, Glutathione Transferase, Proportional Hazards Models
Adult, Polymorphism, Genetic, Genotype, Breast Neoplasms, Valine, Middle Aged, Survival Analysis, Disease-Free Survival, Isoenzymes, Treatment Outcome, Amino Acid Substitution, Glutathione S-Transferase pi, Receptors, Estrogen, Humans, Female, Isoleucine, Aged, Glutathione Transferase, Proportional Hazards Models
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