Analyzing signaling activity and function in hematopoietic cells
Analyzing signaling activity and function in hematopoietic cells
Cells constantly sense their environment, allowing the adaption of cell behavior to changing needs. Fine-tuned responses to complex inputs are computed by signaling pathways, which are wired in complex connected networks. Their activity is highly context-dependent, dynamic, and heterogeneous even between closely related individual cells. Despite lots of progress, our understanding of the precise implementation, relevance, and possible manipulation of cellular signaling in health and disease therefore remains limited. Here, we discuss the requirements, potential, and limitations of the different current technologies for the analysis of hematopoietic stem and progenitor cell signaling and its effect on cell fates.
ISSN:0022-1007
ISSN:1540-0069
ISSN:1540-9538
- ETH Zurich Switzerland
Hematopoiesis; Hematopoietic Stem Cells Focus; Innate immunity and inflammation; Stem Cells & Regeneration
Hematopoiesis; Hematopoietic Stem Cells Focus; Innate immunity and inflammation; Stem Cells & Regeneration
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).0 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Average
Citations provided by BIP!Popularity provided by BIP!