Lack of Arg972 polymorphism in the IRS1 gene in Parakanã brazilian indians

Name: Lack of Arg972 polymorphism in the IRS1 gene in Parakanã brazilian indians
Keywords: Resistência à Insulina, Polimorfismo Genético, Receptor de Insulina

appsOther research productkeyboard_double_arrow_right Other ORP type 26 Jan 2016 English Publisher:Wayne State University Press

Authors: Bezerra, Rosângela M. N; Chadid, Thiago T; Altemani, Cláudia M; Sales, Teresa S. I; Menezes, Raimundo; Soares, Manoel do Carmo Pereira; Saad, Sara T. O; +1 Authors

Lack of Arg972 polymorphism in the IRS1 gene in Parakanã brazilian indians

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Abstract

Several polymorphisms in the insulin receptor substrate-I (IRS I) gene have been reported in the last years. The most common IRSI variant, a Gly -cArg substitution at codon 972 (Arg972 IRS I). is more prevalent among subjects who have features of insulin resistance syndrome associated, or not, with type 2 diabetes in European populations. To determine whether the absence of IRS I polymorphism is a more general characteristic of Paleo-Indian-derived populations, we examined the Arg972 IRSI polymorphism in Parakan5t Indians and found a lack of this polymorphism in the Parakana population.

Universidade Estadual de Campinas. Faculdade de Ciências Médicas. Departamento de Clínica Médica. Campinas, SP, Brasil.

Universidade Estadual de Campinas. Faculdade de Ciêncas Médicas. Departamento de Clínica Médica. Campinas, SP, Brasil.

Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Belém, PA, Brasil.

Keywords

Resistência à Insulina, Polimorfismo Genético, Receptor de Insulina

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