Identifying novel genetic alterations in pediatric acute lymphoblastic leukemia based on copy number analysis
Identifying novel genetic alterations in pediatric acute lymphoblastic leukemia based on copy number analysis
Copy number variations (CNVs) analysis may reveal molecular biomarkers and provide information on the pathogenesis of acute lymphoblastic leukemia (ALL). We investigated the gene copy number in childhood ALL by microarray and select three new recurrent CNVs to evaluate by real-time PCR assay: DMBT1, KIAA0125 and PRDM16 were selected due to high frequency of CNVs in ALL samples and based on their potential biological functions in carcinogenesis described in the literature. DBMT1 deletion was associated with patients with chromosomal translocations and is a potential tumor suppressor; KIAA0125 and PRDM16 may act as an oncogene despite having a paradoxical behavior in carcinogenesis. This study reinforces that microarrays/aCGH is it is a powerful tool for detection of genomic aberrations, which may be used in the risk stratification
National Counsel of Technological and Scientific Development (CNPq), grant n° 460185/2014–4 and Amazon Foundation for Research Support (FAPESPA), grant n° PPSUS/2013.
Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.
Federal University of Pará. Oncology Research Center. Belém, PA, Brazil.
Octávio Lobo Children’s Cancer Hospital. Belém, PA, Brazil.
Leucemia-Linfoma Linfoblástico de Células Precursoras / diagnóstico, Biomarcadores, Leucemia / patologia, Doenças Hematológicas, Variações do Número de Cópias de DNA / genética, Análise Citogenética, Aberrações Cromossômicas
Leucemia-Linfoma Linfoblástico de Células Precursoras / diagnóstico, Biomarcadores, Leucemia / patologia, Doenças Hematológicas, Variações do Número de Cópias de DNA / genética, Análise Citogenética, Aberrações Cromossômicas
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).0 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Average
Citations provided by BIP!Popularity provided by BIP!